Semester III · PCI syllabus 2026
Pharmaceutical Microbiology
BP308T
3 credits
Theory
Coming soon
Unit 1: Introduction and role of microorganisms in pharmaceutical
- industry
- Fundamentals of microbiology: Microorganisms and medicines, Introduction to various microorganisms, Microbial cultivation, isolation and enumeration. Pharmaceutical importance of microorganisms
- Introduction to Microscope (Compound and Electron Microscope)
- Identification of bacteria using staining techniques (simple, Gram‘s &Acid-fast staining) and biochemical tests (IMViC)
- Antibiotics produced by microbiology (Production and uses streptomycin, cephalosporin)
Unit 2: Evaluation of microbiological contamination
- Sources and types of microbial contaminant
- Control of microbial contamination during manufacture of Nonsterile dosage forms and sterile dosage forms (including Aseptic area), control of Atmosphere, Water, Raw material, Facility, Packaging, Equipment
- Microbiological spoilage of pharmaceuticals, Factors affecting microbial spoilage of pharmaceuticals
- Introduction to Fermentation, types and fermenters
Unit 3: Microbial control and evaluation
- Designing of aseptic area. Laminar flow equipment’s, clean area classification, Biological Safety Level categories. Methods of prevention. Disinfectants, antiseptics, and preservatives, and their evaluation, Factors affecting the antimicrobial activity of disinfectants
Unit 4: Sterilization procedures, assurance and evaluation
- Physical, chemical, gaseous, radiation and mechanical methods of sterilization, Advances sterilization technologies, Evaluation of efficiency of sterilization; Validation of sterilization procedures and Sterility indicators
- Sterility assurance, Bioburden determination, Modelling in predicting microbial growth and death, Test for bacteriostatic, bactericidal activity
Unit 5: Microbiological quality control
- Microbial limit tests and Microbial assay (antibiotics, vitamins and amino acids)
- Sterility testing of products according to IP, BP and USP
- Methods for monitoring Water and Air Quality In vitro cell cultures, general procedure for cell culture, Application
Is subject ka content (video/notes) abhi production mein hai — syllabus official PCI curriculum se hai, jaise-jaise units record honge yahan live ho jaayenge.