Physical Pharmaceutics (Practical)

List of Practicals

1. 12 experiments must be performed)
2. Determination of surface tension of given liquids by drop count method and weight method.
3. Determination of critical micellar concentration (CMC) of surfactants.
4. Determination of viscosity of liquids using Ostwald’s viscometer and Brookfield viscometer.
5. Determination of HLB value of a surfactant.
6. Calculation of isotonicity by different methods (Sodium Chloride Equivalent
7. Determination of particle size and particle size distribution using sieving
8. Determination of particle size and particle size distribution using microscopic
9. Determination of densities and derived properties of powders (bulk density, density, Hausner ratio, Carr’s compressibility index), true density, and porosity.
10. Determination of angle of repose and influence of glidants on angle of repose.
11. Determination of solubility of a drug at different pH/buffer systems at room temperature.
12. Determination of partition coefficient of a drug in n-octanol and water system.
13. Determination of partition coefficient of a drug in benzene and water system.
14. Determination of critical solution temperature and composition of phenol–water system.
15. Determination of specific surface area of charcoal by adsorption of acetic activated charcoal.
16. Determination of buffer capacity at various stages of titration of a weak acid strong base and determination of pKa. the values of various physicochemical properties with marketed formulations possible.