Semester VI · PCI syllabus 2026
Pharmaceutical Analysis
BP605T
3 credits
Theory
Coming soon
Unit 1: Electrochemical Methods of analysis
- 1. Potentiometry: Electrode potential, electrochemical cell, construction and working of reference and indicator electrodes pH, potentiometric titrations, methods of detecting end point and Karl Fischer titration
- 2. Conductometry: Introduction, conductivity cell, conductometric titrations and applications
- 3. Polarography: Introduction, residual current, migration current, diffusion current and limiting current, DME, polarographic wave, Ilkovic’s equation (Statement Only), and applications
Unit 2: Spectroscopy
- 1. Fundamentals of Spectroscopy: Properties of electromagnetic radiation, electromagnetic spectrum
- 2. UV Visible spectroscopy: Beer and Lambert’s law, Derivation and deviations. Electronic transitions, chromophores, auxochromes, spectral shifts, solvent effect on absorption spectra, Instrumentation - Sources of radiation, wavelength selectors, sample cells, detectors (Photo tube, Photomultiplier tube, Photo voltaic cell, Silicon Photodiode). Applications - single and multi component analysis of pharmaceuticals
- 3. IR spectroscopy: Introduction, fundamental modes of vibrations in poly atomic molecules, factors affecting vibrations, Instrumentation of dispersive Infrared spectrophotometer (including sample handling Techniques) and FTIR. Pharmaceutical applications
Unit 3: Fluorometric Analysis
- 1. Theory, luminescence, factors affecting fluorescence, quenching. Instrumentation and pharmaceutical applications
- 2. Flame Photometry and Atomic Absorption Spectrometry: Theory, nebulisation, flame and flame temperature, interferences, instrumentation and pharmaceutical applications
- 3. Nepheloturbidometry: Principle, instrumentation and applications
Unit 4: Introduction to Chromatographic Techniques
- 1. Principle, various stationary and mobile phases, diverse development and detection techniques and applications of column, paper and thin layer chromatography
- 2. Ion-exchange chromatography: Introduction, principles, types of ions exchange resins, factors affecting ion exchange, methodology and applications
- 3. Gel filtration and affinity chromatography: Principles and applications
- 4. Electrophoresis: Introduction, factors affecting electrophoretic mobility, Techniques of paper, gel, capillary electrophoresis, applications
Unit 5: 1. Gas chromatography: Introduction, theory, instrumentation,
- derivatization, temperature programming, advantages, disadvantages and applications
- 2. High performance liquid chromatography: Introduction,
- 3. HPTLC: Principle, instrumentation and applications
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