Systemic Pharmacology II (Practical)

List of Practicals

1. 12 experiments must be performed)
2. Evaluation of analgesic activity of centrally and peripherally acting analgesics Eddie's hot plate, tail-flick, tail immersion, and acetic acid-induced writhing through interactive computer simulation.
3. Evaluation of antiepileptic activity using maximal electroconvulsive shock induced seizures through interactive computer simulation.
4. Demonstration of the antiepileptic activity using pentylenetetrazol-induced through interactive computer simulation.
5. Evaluation of antidepressant activity of drugs using the tail suspension test interactive computer simulation.
6. Demonstration and study of locomotor activity using actophotometer through interactive computer simulation.
7. Evaluation of antianxiety activity using the elevated plus maze or zero maze through interactive computer simulation.
8. Evaluation of antipsychotic activity of drugs using inhibition of conditioned on Cook's pole climbing apparatus through interactive computer simulation.
9. Study of the effect of drugs on learning and memory using the Morris water through interactive computer simulation.
10. Study of antiulcer activity using indomethacin-induced or pylorus ligation-induced ulcer models.
11. Estimation of the concentration of oxytocin on isolated rat uterus preparation suitable method through interactive computer-based simulation.
12. Estimation of drug concentration by 3-point or 4-point bioassay through interactive computer simulation.
13. Bioassay of histamine using matching, bracketing, or interpolation methods suitable isolated tissue preparation with the help of interactive computer simulation.
14. Study of cell culture techniques, including types of cell culture, laboratory instruments/equipment, culture media, and growth of cell cultures in laboratory facilities.
15. Study of antibacterial sensitivity testing of urine culture using techniques disc diffusion method (theoretical details/case studies).
16. Demonstration using databases and software packages for predicting drug ADME properties, and toxicity.
17. Study of electrophoresis of protein and DNA samples and gel visualization techniques.
18. Construction of pharmacological networks using predicted drug targets and genes with activity prediction databases, disease gene databases, and suitable software. *PCI recommended software’s shall be used for performing experiments.