Semester V · PCI syllabus 2026
Pharmaceutical Dosage Form II
BP504T
2 credits
Theory
Coming soon
Unit 1: Monophasic Liquids & Pressurised Dosage Forms
- Foundations: Need, advantages/limitations; monophasic vs biphasic; solubility-enhancement techniques. Vehicles & solvents: Pharmaceutical waters (types; manufacturing & Quality Control of Purified/Distilled); classes of solvents as per toxicity. Formulation & manufacturing: Raw-material considerations and additives; processing; Quality Control of solutions/syrups/elixirs; powders for reconstitution as solutions. Measuring, filling & packaging: Techniques; container– closure integrity; automation in liquid manufacturing
Unit 2: Biphasic Liquids - Suspensions
- Formulation & manufacturing: Additives; classification of suspending agents; IPQC & Quality Control; instabilities and packaging. Advances: Nanosuspensions; dry powder for reconstitution as suspensions; raft- forming systems
Unit 3: Biphasic Liquids - Emulsions
- Formulation & manufacturing: Additives; classification of emulsifying agents; IPQC & Quality Control; instabilities and packaging. Advances: Nano-emulsions, micro-emulsions, SMEDDS/SNEDDS (overview, applications)
Unit 4: Pressurized dosage forms (Aerosols/MDIs)
- Concepts; propellant classification/selection; valves & containers; formulation, manufacturing, and Quality Control (leak, spray pattern, delivered dose, particle- size/aerodynamic performance). Dry Powder Inhalers: valves & containers; formulation, manufacturing, and Quality Control
Unit 5: Semisolid Dosage Form
- Theory of Semisolid Dosage Forms: Definition & Purpose, Drug Permeation Pathways through skin ,Factors affecting Permeation, Permeation enhancers: Physical and Chemical. Types of semisolid dosage form:
- Ointments: Base Selection, Formulation , Manufacturing and Evaluation
- Creams: Formulation, Manufacturing and Evaluation
- Pastes: Formulation, Manufacturing and Evaluation
- Suppositories and Pessaries: Formulation, Manufacturing and Evaluation Advances: Xerogels, emulgels (overview, applications)
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